e-Περιοδικό Επιστήμης & Τεχνολογίας

e-Journal of Science & Technology, (e-JST)




Bhupendra G. Prajapati1,*  and Satish N. Patel2


  1. S.K. Patel College of Pharmaceutical Education & Research, Ganpat Vidyanagar, e-mail: bhupen_27@yahoo.co.in, bhupen27@gmail.com

2.      Ganpat University, Kherva. PIN: 382711 City: Mehsana, State: Gujarat, Country: India.


*Corresponding author: Bhupendra G Prajapati, Assistant Professor, S.K. Patel College of Pharmaceutical Education & Research, Ganpat University, Ganpat Vidhyanagar, Kherva -382711, Mehsana, North Gujarat, India.

Contact: bhupen27@gmail.com, Phone: (O) 91-02762-286082




Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, taste, drug content, in vitro disintegrating time and in vitro drug release. Other parameters such as wetting time, water absorption ratio (‘R’), and drug-excipient compatibility were also evaluated. The disintegration time of the optimized CP5 batch was 25 sec. Good correlation was observed between disintegration time and water absorption ratio (R) for each of three superdisintegrants at concentrations studied. Considering the ‘R’ values and disintegration time, crospovidone was significantly superior compared to other two superdisintegrants tested. Release of drug was faster from formulations containing 6% crospovidone (CP5) compared to the marketed convetional Cinnarizine tablet. Differential scanning calorimetric studies did not indicate any excipient incompatibility, either during mixing or after compression. Finally concluded that directly compressible orally disintegrating tablets of cinnarizine with lower friability, acceptable taste, and shorter disintegration times were obtained using crospovidone at optimized concentrations.


KEYWORDS: Cinnarizine, orally disintegrating tablet, wetting time, water absorption ratio.